Sippl, Manfred J.: search on Z-Library

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1

[Methods and Principles in Medicinal Chemistry] Epigenetic Targets in Drug Discovery Volume 42 || Histone Modification Analysis Using Mass Spectrometry

Sippl, Wolfgang, Jung, Manfred

Year:

2009

Language:

english

File:

PDF, 245 KB

english, 2009

2

Recognition of errors in three-dimensional structures of proteins

Dr. Manfred J. Sippl

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1993

Language:

english

File:

PDF, 647 KB

english, 1993

3

Epigenetic drug discovery special issue

Wolfgang Sippl, Manfred Jung

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 118 KB

english, 2011

4

Helmholtz free energies of atom pair interactions in proteins

Manfred J Sippl, Maria Ortner, Markus Jaritz, Peter Lackner, Hannes Flöckner

Journal:

Folding and Design

Year:

1996

Language:

english

File:

PDF, 108 KB

english, 1996

5

Boltzmann's principle, knowledge-based mean fields and protein folding. An approach to the computational determination of protein structures

Manfred J. Sippl

Journal:

Journal of Computer-Aided Molecular Design

Year:

1993

Language:

english

File:

PDF, 1.91 MB

english, 1993

6

Histone deacetylase inhibitors that target tubulin

Jörg Schemies, Wolfgang Sippl, Manfred Jung

Journal:

Year:

2009

Language:

english

File:

PDF, 518 KB

english, 2009

7

Combattre les maladies négligées en ciblant sélectivement leurs enzymes épigénétiques : le cas de la désacétylase 8 (HDAC8) de Schistosoma mansoni

Marek, Martin, Shaik, Tajith B., Jung, Manfred, Sippl, Wolfgang, Pierce, Raymond J., Romier, Christophe

Journal:

Biologie Aujourd hui

Year:

2016

Language:

english

File:

PDF, 1.51 MB

english, 2016

8

Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals)

Schiedel, Matthias, Herp, Daniel, Hammelmann, Sören, Swyter, Sören, Lehotzky, Attila, Robaa, Dina, Oláh, Judit, Ovádi, Judit, Sippl, Wolfgang, Jung, Manfred

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.05 MB

english, 2017

9

Inhibitors to understand molecular mechanisms of NAD+-dependent deacetylases (sirtuins)

Michael Lawson, Urszula Uciechowska, Jörg Schemies, Tobias Rumpf, Manfred Jung, Wolfgang Sippl

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

Year:

2010

Language:

english

File:

PDF, 1.48 MB

english, 2010

10

Intermolecular potentials from crystal data. 6. Determination of empirical potentials for O-H...O = C hydrogen bonds from packing configurations

Sippl, Manfred J., Nemethy, George, Scheraga, Harold A.

Journal:

Journal of Physical Chemistry

Year:

1984

Language:

english

File:

PDF, 321 KB

english, 1984

11

Target-Based Approach to Inhibitors of Histone Arginine Methyltransferases

Spannhoff, Astrid, Heinke, Ralf, Bauer, Ingo, Trojer, Patrick, Metzger, Eric, Gust, Ronald, Schüle, Roland, Brosch, Gerald, Sippl, Wolfgang, Jung, Manfred

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 337 KB

english, 2007

12

Strukturbasierte Entwicklung einer Affinitätssonde für Sirtuin 2

Schiedel, Matthias, Rumpf, Tobias, Karaman, Berin, Lehotzky, Attila, Gerhardt, Stefan, Ovádi, Judit, Sippl, Wolfgang, Einsle, Oliver, Jung, Manfred

Journal:

Angewandte Chemie

Year:

2016

Language:

german

File:

PDF, 1.64 MB

german, 2016

13

Identification and Structure-Activity Relationship Studies of Small-Molecule Inhibitors of the Methyllysine Reader Protein Spindlin1

Robaa, Dina, Wagner, Tobias, Luise, Chiara, Carlino, Luca, McMillan, Joel, Flaig, Ralf, Schüle, Roland, Jung, Manfred, Sippl, Wolfgang

Journal:

Year:

2016

Language:

english

File:

PDF, 1.47 MB

english, 2016

14

Carbamates as Potential Prodrugs and a New Warhead for HDAC Inhibition

King, Kristina, Hauser, Alexander-Thomas, Melesina, Jelena, Sippl, Wolfgang, Jung, Manfred

Journal:

Year:

2018

Language:

english

File:

PDF, 2.82 MB

english, 2018

15

Editorial: Pharmazie in unserer Zeit 3/2010

Theo Dingermann, Manfred Jung, Wolfgang Sippl

Journal:

Pharmazie in unserer Zeit

Year:

2010

Language:

german

File:

PDF, 132 KB

german, 2010

16

Structure-derived hydrophobic potential: Hydrophobic potential derived from X-ray structures of globular proteins is able to identify native folds

Georg Casari, Manfred J. Sippl

Journal:

Journal of Molecular Biology

Year:

1992

Language:

english

File:

PDF, 777 KB

english, 1992

17

The role of histone demethylases in cancer therapy

Hoffmann, Inga, Roatsch, Martin, Schmitt, Martin L., Carlino, Luca, Pippel, Martin, Sippl, Wolfgang, Jung, Manfred

Journal:

Molecular Oncology

Year:

2012

Language:

english

File:

PDF, 1.57 MB

english, 2012

18

Solution of the Embedding Problem and Decomposition of Symmetric Matrices

Manfred J. Sippl and Harold A. Scheraga

Journal:

Proceedings of the National Academy of Sciences

Year:

1985

Language:

english

File:

PDF, 1.26 MB

english, 1985

19

Structure-Based Characterization of Multiprotein Complexes

Wiederstein, Markus, Gruber, Markus, Frank, Karl, Melo, Francisco, Sippl, Manfred J.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.33 MB

english, 2014

20

[Methods and Principles in Medicinal Chemistry] Epigenetic Drug Discovery || Front Matter

Sippl, Wolfgang, Jung, Manfred

Year:

2019

Language:

english

File:

PDF, 115 KB

english, 2019

21

Protein folds from pair interactions: A blind test in fold recognition

Flöckner, Hannes, Domingues, Francisco S., Sippl, Manfred J.

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1997

Language:

english

File:

PDF, 159 KB

english, 1997

22

Assembly of polypeptide and protein backbone conformations from low energy ensembles of short fragments: Development of strategies and construction of models for myoglobin, lysozyme, and thymosin β4

Manfred J. Sippl, Manfred Hendlich, Peter Lackner

Journal:

Protein Science

Year:

1992

Language:

english

File:

PDF, 1.31 MB

english, 1992

23

The role of protein structure in genomics

Francisco S. Domingues, Walter A. Koppensteiner, Manfred J. Sippl

Journal:

Year:

2000

Language:

english

File:

PDF, 228 KB

english, 2000

24

[Methods and Principles in Medicinal Chemistry] Epigenetic Drug Discovery || Index

Sippl, Wolfgang, Jung, Manfred

Year:

2019

Language:

english

File:

PDF, 89 KB

english, 2019

25

Threading thrills and threats

Manfred J Sippl, Hannes Flöckner

Journal:

Year:

1996

File:

PDF, 731 KB

1996

26

Cancer treatment of the future: Inhibitors of histone methyltransferases

Astrid Spannhoff, Wolfgang Sippl, Manfred Jung

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2009

Language:

english

File:

PDF, 745 KB

english, 2009

27

Structure-Based Development of an Affinity Probe for Sirtuin 2

Schiedel, Matthias, Rumpf, Tobias, Karaman, Berin, Lehotzky, Attila, Gerhardt, Stefan, Ovádi, Judit, Sippl, Wolfgang, Einsle, Oliver, Jung, Manfred

Journal:

Angewandte Chemie International Edition

Year:

2016

Language:

english

File:

PDF, 1.71 MB

english, 2016

28

[Methods and Principles in Medicinal Chemistry] Epigenetic Drug Discovery ||

Sippl, Wolfgang, Jung, Manfred

Year:

2019

File:

PDF, 10.68 MB

2019

29

ChemInform Abstract: NAD+-Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets

Joerg Schemies, Urszula Uciechowska, Wolfgang Sippl, Manfred Jung

Journal:

Year:

2011

File:

PDF, 20 KB

2011

30

Superposition of three-dimensional objects: A fast and numerically stable algorithm for the calculation of the matrix of optimal rotation

Manfred J. Sippl, Hans Stegbuchner

Journal:

Computers & Chemistry

Year:

1991

Language:

english

File:

PDF, 591 KB

english, 1991

31

Detection of unrealistic molecular environments in protein structures based on expected electron densities

Simon W. Ginzinger, Christian X. Weichenberger, Manfred J. Sippl

Journal:

Journal of Biomolecular NMR

Year:

2010

Language:

english

File:

PDF, 468 KB

english, 2010

32

Optimum superimposition of protein structures: ambiguities and implications

Feng Zu-Kang, Manfred J Sippl

Journal:

Folding and Design

Year:

1996

Language:

english

File:

PDF, 510 KB

english, 1996

33

Binding free energy calculations and biological testing of novel thiobarbiturates as inhibitors of the human NAD+ dependent histone deacetylase Sirt2

Uciechowska, Urszula, Schemies, Jörg, Scharfe, Michael, Lawson, Michael, Wichapong, Kanin, Jung, Manfred, Sippl, Wolfgang

Journal:

Year:

2012

Language:

english

File:

PDF, 559 KB

english, 2012

34

Cayley--Menger Coordinates

Manfred J. Sippl and Harold A. Scheraga

Journal:

Proceedings of the National Academy of Sciences

Year:

1986

Language:

english

File:

PDF, 707 KB

english, 1986

35

Proteolysis targeting chimeras (PROTACs) for epigenetics research

Vogelmann, Anja, Robaa, Dina, Sippl, Wolfgang, Jung, Manfred

Journal:

Current Opinion in Chemical Biology

Year:

2020

File:

PDF, 1.30 MB

2020

36

Detection of native-like models for amino acid sequences of unknown three-dimensional structure in a data base of known protein conformations

Dr. Manfred J. Sippl, Sabine Weitckus

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1992

Language:

english

File:

PDF, 1.20 MB

english, 1992

37

Detection of Spatial Correlations in Protein Structures and Molecular Complexes

Manfred J. Sippl, Markus Wiederstein

Journal:

Year:

2012

Language:

english

File:

PDF, 2.59 MB

english, 2012

38

Structure-based evaluation of sequence comparison and fold recognition alignment accuracy

Francisco S. Domingues, Peter Lackner, Antonina Andreeva, Manfred J. Sippl

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 376 KB

english, 2000

39

Two-Step Synthesis of Novel, Bioactive Derivatives of the Ubiquitous Cofactor Nicotinamide Adenine Dinucleotide (NAD)

Pesnot, Thomas, Kempter, Julia, Schemies, Jörg, Pergolizzi, Giulia, Uciechowska, Urszula, Rumpf, Tobias, Sippl, Wolfgang, Jung, Manfred, Wagner, Gerd K.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.06 MB

english, 2011

40

An attempt to analyse progress in fold recognition from CASP1 to CASP3

Manfred J. Sippl, Peter Lackner, Francisco S. Domingues, Walter A. Koppensteiner

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1999

Language:

english

File:

PDF, 183 KB

english, 1999

41

Small Molecule Inhibitors of Histone Acetyltransferases as Epigenetic Tools and Drug Candidates

Silviya D. Furdas, Srinivasaraghavan Kannan, Wolfgang Sippl, Manfred Jung

Journal:

Archiv der Pharmazie

Year:

2012

Language:

english

File:

PDF, 290 KB

english, 2012

42

Progress in fold recognition

Hannes Flöckner, Michael Braxenthaler, Peter Lackner, Markus Jaritz, Maria Ortner, Manfred J. Sippl

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1995

Language:

english

File:

PDF, 1.05 MB

english, 1995

43

Computer- and structure-based lead design for epigenetic targets

Ralf Heinke, Luca Carlino, Srinivasaraghavan Kannan, Manfred Jung, Wolfgang Sippl

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.57 MB

english, 2011

44

Biological sequence analysis. Probabilistic models of proteins and nucleic acids, edited by R. Durbin, S. Eddy, A. Krogh, and G. Mitchinson. 1998. Cambridge: Cambridge University Press. 356 pp. £55.00 ($80.00) (hardcover); £19.95 ($34.95) (paper)

Manfred J. Sippl

Journal:

Protein Science

Year:

1999

Language:

english

File:

PDF, 12 KB

english, 1999

45

Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases

Chakrabarti, Alokta, Melesina, Jelena, Kolbinger, Fiona R, Oehme, Ina, Senger, Johanna, Witt, Olaf, Sippl, Wolfgang, Jung, Manfred

Journal:

Future Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 2.96 MB

english, 2016

46

Front Cover: StructureâBased Design, Synthesis, and Biological Evaluation of TriazoleâBased smHDAC8 Inhibitors (ChemMedChem 7/2020)

Kalinin, Dmitrii V., Jana, Sunit K., Pfafenrot, Maxim, Chakrabarti, Alokta, Melesina, Jelena, Shaik, Tajith B., Lancelot, Julien, Pierce, Raymond J., Sippl, Wolfgang, Romier, Christophe, Jung, Manfred

Journal:

Year:

2020

File:

PDF, 1.25 MB

2020

47

Identification of the subtype-selective Sirt5 inhibitor balsalazide through systematic SAR analysis and rationalization via theoretical investigations

Glas, Carina, Dietschreit, Johannes C.B., WÃ¶ssner, Nathalie, Urban, Lars, Ghazy, Ehab, Sippl, Wolfgang, Jung, Manfred, Ochsenfeld, Christian, Bracher, Franz

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 3.70 MB

2020

48

[Methods and Principles in Medicinal Chemistry] Epigenetic Targets in Drug Discovery Volume 42 || New Frontiers in Epigenetic Modifications

Sippl, Wolfgang, Jung, Manfred

Year:

2009

Language:

english

File:

PDF, 252 KB

english, 2009

49

Neutral networks in protein space: a computational study based on knowledge-based potentials of mean force

Aderonke Babajide, Ivo L Hofacker, Manfred J Sippl, Peter F Stadler

Journal:

Folding and Design

Year:

1997

Language:

english

File:

PDF, 218 KB

english, 1997

50

[Methods and Principles in Medicinal Chemistry] Epigenetic Drug Discovery ||

Sippl, Wolfgang, Jung, Manfred

Year:

2019

Language:

english

File:

PDF, 10.68 MB

english, 2019

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